Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention.

Abstract

OBJECTIVE:

This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention (PCI).

METHODS:

The present study examined serial changes (5 min, 30 min, 2 h, 6 h, and 24 h after PCI) in circulating P-selectin, plasminogen activator inhibitor-1 (PAI-1), magnesium (Mg), and creatine kinase-myocardial band fraction (CK-MB) levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up.

RESULTS:

PCI induced an early elevation of P-selectin, which correlated positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-1. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respectively.

CONCLUSIONS:

Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI.

• Authors: Shu-qin Ying, Mei-xiang Xiang, Lu Fang, Jian-an Wang
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 11 Issue 8 Pg. 575-82 (Aug 2010) ISSN: 1862-1783 [Electronic] China
• PMID: 20669347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• P-Selectin
• Plasminogen Activator Inhibitor 1
• Creatine Kinase
• Magnesium

Topics

• Adult
• Aged
• Aged, 80 and over
• Angioplasty (methods)
• Coronary Angiography (methods)
• Coronary Restenosis (pathology)
• Creatine Kinase (biosynthesis)
• Female
• Humans
• Magnesium (chemistry)
• Male
• Middle Aged
• P-Selectin (blood)
• Plasminogen Activator Inhibitor 1 (blood)
• Reperfusion Injury
• Time Factors