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Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment.

Abstract
Cryptogenic organizing pneumonia (formerly known as bronchiolitis obliterans organizing pneumonia) is a clinicopathological entity with characteristical radiographic findings such as bilateral, asymmetrical, sometimes migrating, patchy infiltrates in chest radiograph and ground-glass opacities in computed tomography. The disease has been observed in the context of gastrointestinal disorders, certain lung infections, autoimmune-mediated diseases (such as Wegener granulomatosis), inhalation of toxic fumes, bone marrow transplantation and administration of drugs. The benzofuran amiodarone, a commonly used antiarrythmic drug for atrial fibrillation, can exhibit several pulmonary adverse effects, amongst them cryptogenic organizing pneumonia as a rarely diagnosed and published one. We report a case of cryptogenic organizing pneumonia secondary to amiodarone treatment, its clinical course with significant improvement of clinical symptoms within a few days after discontinuation of amiodarone treatment and administration of corticosteroids. Also the infiltrations found in chest X-ray and computed tomography responded well and showed remarkable resolution tendency quickly. During 5 months of corticoid therapy pulmonary abnormalities gradually resolved almost completely and remained equal during the 8 months follow-up after corticoid termination.
AuthorsKatja Schindler, Wolfgang Schima, Josef F Kaliman
JournalWiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 122 Issue 15-16 Pg. 511-4 (Aug 2010) ISSN: 1613-7671 [Electronic] Austria
PMID20668958 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Anti-Arrhythmia Agents
  • Amiodarone
Topics
  • Adrenal Cortex Hormones (adverse effects)
  • Aged
  • Amiodarone (adverse effects)
  • Anti-Arrhythmia Agents (adverse effects)
  • Cryptogenic Organizing Pneumonia
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male

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