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Suppression of S-phase kinase-associated protein 2 induces apoptosis and inhibits tumor growth in human laryngeal cancer.

Abstract
S-phase kinase-associated protein 2 (Skp2) is related to cellular proliferation and differentiation in laryngeal carcinoma. This study aimed to investigate the effect of Skp-2 suppression on p27 expression, cellular proliferation, apoptosis, and tumor growth in laryngeal squamous cell carcinoma. Skp2 was stably suppressed in Hep2 laryngeal carcinoma cells by lentivirus siRNA technology and Hep2-siRNA was then inoculated into nude mice. The siRNA-induced suppression of Skp2 increased p27 expression, decreased cellular proliferation, and increased apoptosis in human laryngeal carcinoma cells and tumors, indicating that Skp2 is a viable target in the gene therapy treatment of human laryngeal carcinoma.
AuthorsJiangtao Liu, Lijun Tan, Huijun Li, Qiwei Wang, Wenyue Ji
JournalORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 72 Issue 4 Pg. 205-14 ( 2010) ISSN: 1423-0275 [Electronic] Switzerland
PMID20668394 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2010 S. Karger AG, Basel.
Chemical References
  • Proliferating Cell Nuclear Antigen
  • RNA, Small Interfering
  • S-Phase Kinase-Associated Proteins
  • p27 antigen
Topics
  • Animals
  • Apoptosis (physiology)
  • Carcinoma, Squamous Cell (enzymology, pathology)
  • Cell Proliferation
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Laryngeal Neoplasms (enzymology, pathology)
  • Mice
  • Polymerase Chain Reaction
  • Proliferating Cell Nuclear Antigen (biosynthesis, genetics)
  • RNA, Small Interfering (genetics)
  • S-Phase Kinase-Associated Proteins (genetics, metabolism)
  • Tumor Cells, Cultured

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