Regular daily intake of black tea improves oxidative stress biomarkers and decreases serum C-reactive protein levels in type 2 diabetic patients.

Abstract

BACKGROUND:

This study was undertaken to evaluate the possible effects of different daily doses of black tea intake on certain oxidative stress, inflammatory and metabolic biomarkers in patients with type 2 diabetes mellitus (T2DM).

METHODS:

Forty-six patients with known T2DM were randomly assigned either to the test (n = 23, 57.0 +/- 7.9 years) or the control (n = 23, 55.4 +/- 8.3 years) group. Following a one-week 'run-in' period, the test group received 150, 300, 450 and 600 ml of black tea extract (BTE) during the weeks 1, 2, 3 and 4, respectively. The control group received 150 ml BTE a day throughout the intervention period. Dietary, anthropometric and biochemical assessments were performed at the end of each week.

FINDINGS:

Serum total antioxidant capacity was enhanced similarly in both test and control groups. However, daily intake of 2 cups of BTE by the test group showed a suppressing effect on serum malondialdehyde. Serum C-reactive protein significantly decreased and glutathione levels increased following the intake of 4 cups (600 ml) of BTE a day.

CONCLUSION:

Regular intake of BTE had anti-oxidative and anti-inflammatory effects in patients with T2DM. These findings may, to some extent, explain the mechanisms underlying the protective effects of drinking tea against cardiovascular disease.

• Authors: Tirang R Neyestani, Nastaran Shariatzade, Ali Kalayi, A'azam Gharavi, Niloufar Khalaji, Monireh Dadkhah, Telma Zowghi, Homa Haidari, Sakineh Shab-bidar
• Journal: Annals of nutrition & metabolism (Ann Nutr Metab) Vol. 57 Issue 1 Pg. 40-9 ( 2010) ISSN: 1421-9697 [Electronic] Switzerland
• PMID: 20668372 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: 2010 S. Karger AG, Basel.

Chemical References

• Antioxidants
• Biomarkers
• Plant Extracts
• Tea
• Malondialdehyde
• C-Reactive Protein

Topics

• Antioxidants (metabolism)
• Biomarkers
• C-Reactive Protein (drug effects)
• Camellia sinensis (chemistry)
• Diabetes Mellitus, Type 2 (drug therapy)
• Female
• Humans
• Male
• Malondialdehyde (blood)
• Middle Aged
• Oxidative Stress (drug effects)
• Plant Extracts (pharmacology)
• Tea (chemistry)