Abstract | BACKGROUND: METHODS: RESULTS:
Fatigue increased significantly (p < .001) and citrulline decreased significantly (p < .001) during treatment. A significant negative correlation (r = -0.40; p < .05) was found between fatigue and epithelial atrophy in the intestine (as assessed by plasma citrulline) after 3 weeks of treatment and a significant positive correlation (r = 0.75; p < .001) was found between fatigue and diarrhea. Signs of systemic inflammation were evident, with significant increases in serum orosomucoid, serum haptoglobin (p < .05) and serum α(1)-antitrypsin (p < .001) and a significant decrease in serum albumin (p < .001). CONCLUSION: The present study indicates a link between fatigue and intestinal injury during pelvic radiotherapy. This observation should be considered as a preliminary finding because of the small sample size but may serve as a rationale for therapeutic interventions aimed at alleviating both fatigue and gastrointestinal symptoms during pelvic radiotherapy.
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Authors | Sofie Jakobsson, Karin Ahlberg, Charles Taft, Tor Ekman |
Journal | The oncologist
(Oncologist)
Vol. 15
Issue 9
Pg. 1009-15
( 2010)
ISSN: 1549-490X [Electronic] England |
PMID | 20667967
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Orosomucoid
- Citrulline
- C-Reactive Protein
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Topics |
- Aged
- Aged, 80 and over
- C-Reactive Protein
(analysis)
- Citrulline
(blood)
- Diarrhea
(etiology)
- Fatigue
(etiology)
- Female
- Humans
- Intestines
(radiation effects)
- Middle Aged
- Orosomucoid
(analysis)
- Pelvis
(radiation effects)
- Prospective Studies
- Uterine Neoplasms
(radiotherapy)
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