Abstract | PURPOSE: The aim of this study was to compare the results of semiquantitative analysis by(18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) with plasma osteopontin levels in the same asbestos-related pleural disease population. MATERIALS AND METHODS: A total of 17 patients with asbestos-related pleural disease were prospectively recruited. They underwent PET/CT, and plasma osteopontin levels were measured. The maximum standardized uptake value (SUVmax) was determined from the most active pleural lesion in each patient. RESULTS:
Malignant pleural mesothelioma (MPM) was histologically proven in 6 patients, and 11 patients had proven benign asbestos-related pleural diseases (7 pleural plaques, 4 asbestos pleurisy). Significant differences in SUVmax were found between patients with MPM and those with asbestos pleurisy (P = 0.031) and between patients with MPM and those with pleural plaques (P = 0.012). A significant difference was found in the plasma osteopontin levels between patients with asbestos pleurisy and patients with pleural plaques (Bonferroni correction, P = 0.024). The SUVmax in patients with benign asbestos-related diseases was statistically positively correlated with plasma osteopontin in the same group (Spearman's r = 0.75, P < 0.05). CONCLUSION:
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Authors | Seiji Kurata, Masatoshi Ishibashi, Koichi Azuma, Hayato Kaida, Shinzo Takamori, Kiminori Fujimoto, Maiko Kobayashi, Yasumitsu Hirose, Hisamichi Aizawa, Naofumi Hayabuchi |
Journal | Japanese journal of radiology
(Jpn J Radiol)
Vol. 28
Issue 6
Pg. 446-52
(Jul 2010)
ISSN: 1867-108X [Electronic] Japan |
PMID | 20661695
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
- Osteopontin
- Asbestos
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Topics |
- Aged
- Aged, 80 and over
- Asbestos
(blood, toxicity)
- Diagnosis, Differential
- Female
- Fluorodeoxyglucose F18
- Humans
- Imaging, Three-Dimensional
(methods)
- Male
- Mesothelioma
(blood, diagnostic imaging, etiology)
- Middle Aged
- Osteopontin
(blood)
- Pleura
(diagnostic imaging)
- Pleural Diseases
(blood, diagnostic imaging, etiology)
- Pleural Neoplasms
(blood, diagnostic imaging)
- Pleurisy
(blood, diagnostic imaging)
- Positron-Emission Tomography
(methods)
- Prospective Studies
- Radiopharmaceuticals
- Tomography, Spiral Computed
(methods)
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