Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum).

Abstract

This case-series describes fourteen horses suspected of equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) also known as atypical myopathy of which seven cases were confirmed biochemically with all horses having had access to leaves of the Maple tree (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Assessment of organic acids, glycine conjugates, and acylcarnitines in urine was regarded as gold standard in the biochemical diagnosis of equine acquired multiple acyl-CoA dehydrogenase deficiency.

• Authors: J H van der Kolk, I D Wijnberg, C M Westermann, L Dorland, M G M de Sain-van der Velden, L C Kranenburg, M Duran, J A Dijkstra, J J van der Lugt, R J A Wanders, E Gruys
• Journal: Molecular genetics and metabolism (Mol Genet Metab) 2010 Oct-Nov Vol. 101 Issue 2-3 Pg. 289-91 ISSN: 1096-7206 [Electronic] United States
• PMID: 20655779 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Carboxylic Acids
• acylcarnitine
• Carnitine
• Glycine

Topics

• Acer
• Animals
• Ascomycota
• Carboxylic Acids (urine)
• Carnitine (analogs & derivatives, urine)
• Female
• Foodborne Diseases (veterinary)
• Glycine (urine)
• Horse Diseases (enzymology, urine)
• Horses
• Male
• Multiple Acyl Coenzyme A Dehydrogenase Deficiency (veterinary)
• Plant Diseases (microbiology)
• Plant Leaves