Abstract | BACKGROUND: STUDY DESIGN: Sixty women were randomized into study group [ethinylestradiol (EE) 30 mcg+drospirenone 3 mg] and control group (EE 30 mcg+desogestrel 150 mcg), treated for 6 months and followed up at 1 month, 3 months, 6 months, during treatment and 3 and 6 months post-treatment. Acne and hirsutism scoring, bodyweight, body mass index (BMI), blood pressure (BP), ultrasound parameters, lipid profile, glycemic profile and hormonal profile were compared. RESULTS: Cycles were regular in both groups during treatment. Effect of regular cycles persisted in 44.83% (13/30) vs. 17.24% (5/30) in study vs. control group at 6 months post-treatment with 33.3% decreased hirsutism score in the study group (versus no change in control group) even at 6 months after stopping treatment. With treatment, BMI fell by 0.52 kg/m(2) in the study group; systolic and diastolic BP fell in the study group while it rose in the control group. Low-density lipoprotein significantly decreased and high-density lipoprotein was elevated in the study group (p<.05). The study group showed a significant fall in fasting/postprandial blood sugar and insulin and total testosterone against a rise in the control group. CONCLUSION: In women with PCOS, a drospirenone containing COC has better outcome in terms of persistent regular cycles, antiandrogenic effect, fall in BMI and BP, better lipid profile, favorable glycemic and hormonal profile than desogestrel-containing COC.
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Authors | Alka Kriplani, Anurekha Janaki Periyasamy, Nutan Agarwal, Vidushi Kulshrestha, Anand Kumar, Ariachery Chinnama Ammini |
Journal | Contraception
(Contraception)
Vol. 82
Issue 2
Pg. 139-46
(Aug 2010)
ISSN: 1879-0518 [Electronic] United States |
PMID | 20654754
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Androstenes
- Blood Glucose
- Contraceptives, Oral, Combined
- Drug Combinations
- Insulin
- Lipoproteins, HDL
- Lipoproteins, LDL
- Triglycerides
- drospirenone and ethinyl estradiol combination
- Testosterone
- Ethinyl Estradiol
- Desogestrel
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Topics |
- Acne Vulgaris
(metabolism)
- Adolescent
- Adult
- Androstenes
(pharmacology, therapeutic use)
- Anthropometry
- Blood Glucose
(analysis)
- Blood Pressure
(physiology)
- Contraceptives, Oral, Combined
(pharmacology, therapeutic use)
- Desogestrel
(pharmacology, therapeutic use)
- Drug Combinations
- Ethinyl Estradiol
(pharmacology, therapeutic use)
- Female
- Hirsutism
(metabolism)
- Humans
- Insulin
- Lipoproteins, HDL
(blood)
- Lipoproteins, LDL
(blood)
- Polycystic Ovary Syndrome
(drug therapy, metabolism)
- Prospective Studies
- Statistics, Nonparametric
- Testosterone
- Triglycerides
(blood)
- Young Adult
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