Frequent expression of thymidine phosphorylase in Epstein-Barr virus-associated gastric carcinoma of diffuse type.

Abstract

UNLABELLED:

The aim of the present study was to elucidate the etiological roles of Epstein-Barr virus (EBV) in the development of EBV-associated GC (EBV-GC), EBV-GCs and non EBV-GCs were compared with regard to the expression of thymidine phosphorylase (TP), which is known to have angiogenic activity in various tumor tissues.

PATIENTS AND METHODS:

TP expression was examined by immunohistochemistry assay among 156 gastric carcinoma cases (21 EBV-GC cases and 135 non EBV-GC cases).

RESULTS:

The frequency of tumors with TP expression was nearly twice as high in EBV-GCs (71%) than in non EBV-GCs (37%) (p=0.005). However, such an association was only observed in Lauren's diffuse-type tumors.

CONCLUSION:

Our finding suggests that the mechanism involved in TP expression of gastric carcinoma appears to be different in intestinal- and diffuse-type tumors.

• Authors: Chihaya Koriyama, Suminori Akiba, Shunji Shimaoka, Tetsuhiko Itoh, Shin-ichi Akiyama, Yoshito Eizuru
• Journal: Anticancer research (Anticancer Res) Vol. 30 Issue 6 Pg. 2431-7 (Jun 2010) ISSN: 1791-7530 [Electronic] Greece
• PMID: 20651404 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ki-67 Antigen
• RNA, Viral
• Tumor Necrosis Factor-alpha
• Interferon-gamma
• Thymidine Phosphorylase

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Herpesvirus 4, Human (genetics, isolation & purification)
• Humans
• Interferon-gamma (genetics)
• Ki-67 Antigen (analysis)
• Male
• Middle Aged
• RNA, Viral (analysis)
• Stomach Neoplasms (enzymology, pathology, virology)
• Thymidine Phosphorylase (analysis)
• Tumor Necrosis Factor-alpha (genetics)