Plasma thiobarbituric acid reactive substances a predictive marker of cerebral ischemia in patients at high risk?

Abstract

The clinical meaning of high values of blood lipid peroxides, assessed as thiobarbituric acid reactive substances (TBA-RS), was investigated in 19 selected high risk patients with transient ischemic attacks (TIA). Patients were checked every 3-6 months and followed-up for 3 years. 8 patients experienced further vascular episodes, 4 having minor stroke and 4 TIA; one of the latter died from myocardial infarction. Unlike blood cholesterol and glucose. TBA-RS values discriminated patients with vascular episodes: they, indeed, showed significant higher values of TBA-RS. Discriminant analysis further indicated that TBA-RS levels differentiate patients with and without vascular accidents, suggesting that high blood values of lipid peroxides could represent a predictive sign of vascular ischemia.

• Authors: C Alessandri, M Germani, C Censi, G Rudelli, L Iuliano, M Servi, A Ghiselli, F Violi
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 83 Issue 5 Pg. 323-7 (May 1991) ISSN: 0001-6314 [Print] Denmark
• PMID: 2063655 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Lipid Peroxides
• Thiobarbiturates
• Triglycerides
• Cholesterol
• thiobarbituric acid

Topics

• Aged
• Blood Glucose (metabolism)
• Cerebral Infarction (blood, diagnosis)
• Cholesterol (blood)
• Female
• Follow-Up Studies
• Humans
• Intracranial Arteriosclerosis (blood, diagnosis)
• Ischemic Attack, Transient (blood, diagnosis)
• Lipid Peroxides (blood)
• Male
• Middle Aged
• Recurrence
• Risk Factors
• Thiobarbiturates (pharmacokinetics)
• Triglycerides (blood)