Abstract |
Multiple myeloma is an immunologically relevant disease, which subverts and suppresses immunity, but that may also be amenable to immunological control. Novel drug and cell-based therapies provide an opportunity for the design of antimyeloma immunotherapy. Reversing the immunosuppression associated myeloma remains a substantial challenge. The minimal residual disease setting achieved by autologous stem cell transplant or highly efficacious induction therapy may reverse this immunoparesis and provide a setting for induction of antimyeloma T-cell responses. Adoptive cytotoxic T-lymphocyte/NK therapy and comprehensive treatment with immunomodulatory drug therapy represent means by which antimyeloma immune responses may be promoted. In addition, apoptosis-inducing therapies may prime endogenous antigen presentation via immunogenic cell death, which again may be enhanced by the addition of immunomodulatory drug therapy.
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Authors | David S Ritchie, Hang Quach, Kate Fielding, Paul Neeson |
Journal | Immunotherapy
(Immunotherapy)
Vol. 2
Issue 2
Pg. 243-55
(Mar 2010)
ISSN: 1750-7448 [Electronic] England |
PMID | 20635931
(Publication Type: Journal Article, Review)
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Chemical References |
- Antigens, Neoplasm
- Antineoplastic Agents
- Boronic Acids
- Cancer Vaccines
- Immunologic Factors
- Pyrazines
- Thalidomide
- Bortezomib
- Lenalidomide
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Topics |
- Antibody-Dependent Cell Cytotoxicity
- Antigens, Neoplasm
(immunology)
- Antineoplastic Agents
(therapeutic use)
- Apoptosis
(drug effects)
- Boronic Acids
(therapeutic use)
- Bortezomib
- Cancer Vaccines
(therapeutic use)
- Combined Modality Therapy
- Forecasting
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunologic Factors
(therapeutic use)
- Immunologic Memory
- Immunotherapy
(methods)
- Immunotherapy, Active
- Immunotherapy, Adoptive
- Killer Cells, Natural
(immunology, transplantation)
- Lenalidomide
- Multiple Myeloma
(drug therapy, immunology, surgery, therapy)
- Pyrazines
(therapeutic use)
- T-Lymphocytes, Cytotoxic
(immunology, transplantation)
- T-Lymphocytes, Regulatory
(immunology)
- Thalidomide
(analogs & derivatives, therapeutic use)
- Tumor Escape
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