Electrophysiological effects, efficacy and safety of intravenous propafenone in termination of atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia: a prospective non-randomized interventional study.

Abstract

The aim of this prospective, non-randomized interventional study was to assess electrophysiological effects, efficacy and safety of intravenous propafenone in termination of atrioventricular nodal reentrant tachycardia (AVNRT) and orthodromic atrioventricular reentrant tachycardia (AVRT). This single-center study was carried out at Department of Cardiology, Sestre milosrdnice University Hospital in Zagreb, Croatia, between January 1, 2005 and December 31, 2006. Eligibility requirements were fulfilled by a total of 70 patients with AVNRT (n=37) and AVRT (n=33). The intervention consisted of the electrophysiological study aimed at inducing tachycardia, followed by intravenous administration of 2 mg/kg propafenone in both groups. The main outcome measures were safety and efficacy of 2 mg/kg intravenous propafenone in tachycardia termination and re-induction. Out of 37 patients with AVNRT, propafenone managed to terminate it in 28 (75.7%) patients, while tachycardia was not inducible in 25 (67.56%) patients. Out of 33 patients with AVRT, propafenone managed to terminate AVRT in 29 (87.9%) patients, while tachycardia was not inducible in 22 (66.66%) patients. The overall propafenone efficacy in tachycardia termination was 81.42%. No propafenone-related adverse effects were recorded during the study period. Propafenone was found to be a safe and effective anti-arrhythmic drug and can be justifiably administered for AVNRT and AVRT termination. It could be considered as an alternative to adenosine and verapamil.

• Authors: Hrvoje Pintarić, Sime Manola, Janko Szavits Nossan, Nikola Pavlović, Diana Delić-Brkljacić, Vjekoslav Radeljić
• Journal: Acta clinica Croatica (Acta Clin Croat) Vol. 49 Issue 1 Pg. 25-31 (Mar 2010) ISSN: 0353-9466 [Print] Croatia
• PMID: 20635581 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propafenone

Topics

• Adolescent
• Adult
• Aged
• Anti-Arrhythmia Agents (administration & dosage)
• Electrophysiologic Techniques, Cardiac
• Female
• Humans
• Infusions, Intravenous
• Injections, Intravenous
• Male
• Middle Aged
• Propafenone (administration & dosage)
• Tachycardia, Atrioventricular Nodal Reentry (drug therapy, physiopathology)
• Young Adult