Creation of large elastase-induced aneurysms: presurgical arterial remodeling using arteriovenous fistulas.

Abstract

BACKGROUND AND PURPOSE:

The size of elastase-induced aneurysms created in the usual way is relatively small. Our aim was to determine whether creation of a carotid-jugular AVF to induce remodeling of the RCCA results in larger elastase-induced aneurysms in rabbits.

MATERIALS AND METHODS:

RCCA right-jugular AVFs were created in 6 New Zealand white rabbits (group 1), followed by elastase-induced aneurysm creation 4 weeks later. Follow-up DSA was performed to assess AVF patency and aneurysm sizes. Six other elastase-induced aneurysms created in the usual way were used as controls (group 2). The diameters of the RCCA and LCCA in group 1 and aneurysm sizes in both groups were measured from DSA images and compared by using the Student t test.

RESULTS:

The patency of AVFs in group 1 was confirmed in all 6 (100%) cases. The mean RCCA diameter in group 1 was larger than that in the contralateral LCCA (3.6 ± 0.7 mm versus 2.0 ± 0.1 mm, range, 1.8-2.2 mm, P < .01). The mean aneurysm neck diameter, width, and height for group 1 was larger than those of group 2 (4.6 ± 0.9 mm versus 3.5 ± 0.7 mm, P < .05; 4.7 ± 1.1 mm versus 3.4 ± 0.5 mm, P < .05; 13.8 ± 3.2 mm versus 8.1 ± 1.3 mm, P < .05, respectively). Aneurysm volume for group 1 was significantly larger than that of group 2 (273 ± 172 mm³ versus 77 ± 32 mm³, P < .05).

CONCLUSIONS:

Carotid-jugular AVFs result in RCCA remodeling that yields relatively larger elastase-induced aneurysms.

• Authors: Y Ding, D Dai, R Kadirvel, D A Lewis, D F Kallmes
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 31 Issue 10 Pg. 1935-7 (Nov 2010) ISSN: 1936-959X [Electronic] United States
• PMID: 20634302 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Pancreatic Elastase

Topics

• Angiography, Digital Subtraction
• Animals
• Arteriovenous Fistula (chemically induced, diagnostic imaging)
• Carotid Artery Diseases (chemically induced, diagnostic imaging)
• Carotid Artery, Common (diagnostic imaging)
• Disease Models, Animal
• Jugular Veins (diagnostic imaging)
• Pancreatic Elastase (toxicity)
• Preoperative Period
• Rabbits