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Cancer malignancy is enhanced by glyceraldehyde-derived advanced glycation end-products.

Abstract
The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEs did not. However, the effects of Glycer-AGEs on other cancer cells remain poorly understood, and the molecular mechanisms behind the above-mentioned effect have not been clarified. The present paper aimed to examine the effect of Glycer-AGEs on cultured lung cancer A549 cells. RAGE was expressed in A549 cells. Glycer-AGEs significantly attenuated cell proliferation. Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity. We demonstrated that Glycer-AGEs enhanced the migration and invasion of A549 cells rather than their proliferation. These results suggest that Glycer-AGEs play a critical role in the malignancy of cancer rather than its proliferation and are potential targets for therapeutic intervention.
AuthorsJun-Ichi Takino, Sho-Ichi Yamagishi, Masayoshi Takeuchi
JournalJournal of oncology (J Oncol) Vol. 2010 Pg. 739852 ( 2010) ISSN: 1687-8469 [Electronic] Egypt
PMID20631911 (Publication Type: Journal Article)

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