[Kawasaki disease: Diagnosis and treatment].

Abstract

INTRODUCTION:

Kawasaki disease is the leading cause of acquired heart disease in children. In spite of the efficacy of intravenous immunoglobulin (IGIV), the absence of a specific diagnostic test and due to there being IGIV-refractory patients, Kawasaki disease is a major cause of coronary artery abnormalities (CAA).

OBJECTIVES:

To analyze the clinical and epidemiological characteristics of cases of Kawasaki disease, to evaluate the efficacy of treatments used and the CAA observed.

METHODS:

We retrospectively reviewed the medical records of children diagnosed with Kawasaki disease between January 2002 and December 2008 in a tertiary public Hospital in the South of Madrid. The diagnosis of Kawasaki disease was based on the clinical criteria proposed by the American Academy of Pediatrics in 2004.

RESULTS:

Twenty three children were identified. Median age was 26 months (range: 2 months-10 years). Nineteen children (82%) were younger than 5 years old. Fever and changes in the lips and oral cavity were present in all cases. Twenty-one patients (91%) received IGIV, all of them before the 10th day of disease. One child (4.7%) required the administration of more than one dose of IGIV, because persistence of fever. CAA was recorded in three patients [13.0%, (95% CI: 1-26%)], including a four month-old boy. All patients with CAA were treated with the recommended dose of IGIV, 2g/kg, between the 5th and 8th day of disease.

CONCLUSIONS:

Kawasaki disease was more common in children less than five years old. We observed a high rate of CAA in children with Kawasaki disease in spite of appropriate and timely treatment.

• Authors: L M Prieto Tato, M T Cuesta Rubio, S Guillén Martín, M Ruiz Jiménez, M T Cortés Coto, B Rubio Gribble, J T Ramos Amador
• Journal: Anales de pediatria (Barcelona, Spain : 2003) (An Pediatr (Barc)) Vol. 73 Issue 1 Pg. 25-30 (Jul 2010) ISSN: 1695-9531 [Electronic] Spain
• Vernacular Title: Enfermedad de Kawasaki: diagnóstico y tratamiento.
• PMID: 20630417 (Publication Type: English Abstract, Journal Article)
• Copyright: 2009 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

Topics

• Child
• Child, Preschool
• Female
• Humans
• Infant
• Male
• Mucocutaneous Lymph Node Syndrome (diagnosis, therapy)
• Retrospective Studies