Efficacy of photodynamic therapy with topical 5-aminolevulinic acid using intense pulsed light for Bowen's disease.

Abstract

Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is reported to be an effective and safe treatment for superficial non-melanoma skin cancers. We have developed an photodynamic therapy with topical delta-aminolevulinic acid (ALA-PDT) protocol using intense pulsed light (IPL) for treating Bowen's disease (BD). Three patients diagnosed with BD by skin biopsy were recruited in this study. They received IPL treatment after 3 h of occlusive dressing with application of ALA. This protocol was repeated every 2 weeks for a total of five sessions. The treated areas did not show any signs of BD for more than 1 year; therefore, it appeared that the affected areas showed improvement in all the patients. No patients withdrew from the study because of side-effects. ALA-PDT with IPL as a light source is well tolerated by patients and is beneficial for treating BD.

• Authors: Toshio Hasegawa, Yasushi Suga, Yuki Mizuno, Kunitaka Haruna, Hideoki Ogawa, Shigaku Ikeda
• Journal: The Journal of dermatology (J Dermatol) Vol. 37 Issue 7 Pg. 623-8 (Jul 2010) ISSN: 1346-8138 [Electronic] England
• PMID: 20629828 (Publication Type: Case Reports, Journal Article)

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aged, 80 and over
• Aminolevulinic Acid (therapeutic use)
• Bowen's Disease (drug therapy, pathology)
• Female
• Humans
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Skin Neoplasms (drug therapy, pathology)
• Treatment Outcome