Abstract | OBJECTIVE: METHODS: After 4min of untreated ventricular fibrillation, animals were randomly treated with nifekalant (2mgkg(-1)), amiodarone (5mgkg(-1)) or saline placebo (n=12 pigs per group). Precordial compression and ventilation were initiated after drug administration and defibrillation was attempted 2min later. Hemodynamics were continuously measured for 6h after successful resuscitation. RESULTS: CONCLUSION:
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Authors | Xian-Fei Ji, Chun-Sheng Li, Shuo Wang, Lin Yang, Lu-Hong Cong |
Journal | Resuscitation
(Resuscitation)
Vol. 81
Issue 8
Pg. 1031-6
(Aug 2010)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 20627529
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Arrhythmia Agents
- Pyrimidinones
- nifekalant
- Amiodarone
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Topics |
- Amiodarone
(administration & dosage)
- Animals
- Anti-Arrhythmia Agents
(administration & dosage)
- Cardiopulmonary Resuscitation
(methods)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Heart Arrest
(etiology, physiopathology, prevention & control)
- Heart Rate
(drug effects, physiology)
- Male
- Pyrimidinones
(administration & dosage)
- Swine
- Treatment Outcome
- Ventricular Fibrillation
(complications, drug therapy, physiopathology)
- Ventricular Function
(drug effects)
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