Anaphylaxis complicating graft reperfusion during orthotopic liver transplantation: a case report.

Abstract

Hemodynamic instability may occur during liver transplantation especially following unclamping the portal vein. A period of hypotension (postreperfusion syndrome) is usually responsive to treatment with fluids, calcium, sodium bicarbonate, and vasoactive drugs, but if hypotension persists, other causes must be sought out. In this report, we present a case in which anaphylaxis, most likely due to a component of the University of Wisconsin preservation solution, occurred coincident with liver reperfusion and severely exacerbated reperfusion hemodynamic instability. To our knowledge, this is the first report of anaphylaxis at the time of reperfusion and may provide an explanation for cases of vasoplegic syndrome associated with graft reperfusion.

• Authors: A Anderson, H Eilers, C Spencer Yost
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 5 Pg. 1967-9 (Jun 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 20620557 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vasopressins
• Phenylephrine
• Dopamine

Topics

• Alcoholism (complications)
• Anaphylaxis (complications)
• Bile (metabolism)
• Blood Pressure (drug effects, physiology)
• Dopamine (therapeutic use)
• Hepatitis C, Chronic (complications, surgery)
• Humans
• Liver Transplantation (adverse effects)
• Male
• Middle Aged
• Phenylephrine (therapeutic use)
• Reperfusion Injury (complications)
• Respiration, Artificial (methods)
• Treatment Outcome
• Vasopressins (therapeutic use)