Abstract | BACKGROUND: METHODS: Male Wistar rats were randomly divided into 3 groups. The sham group (n = 7), did not undergo BD. Both donor and recipient rats in the BD biliverdin group (n = 8) were injected with biliverdin (35 mg/kg in 1 mL) intraperitoneally after confirmed BD and transplantation. In the BD group (n = 8), both donor and recipient rats received the same volume of saline (35 mg/kg in 1 mL) as the BD biliverdin group. All donor rats were observed for 1.5 hours before undergoing lung transplantation. Two hours after transplantation, we obtained blood and lung graft samples. RESULTS: CONCLUSION:
Biliverdin exerts protective effects on lung grafts from BD donors through anti-inflammatory, antioxidant, and anti-apoptotic mechanisms.
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Authors | J Wang, H-C Zhou, P Pan, N Zhang, W-Z Li |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 42
Issue 5
Pg. 1602-9
(Jun 2010)
ISSN: 1873-2623 [Electronic] United States |
PMID | 20620483
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-8
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Peroxidase
- Biliverdine
- Bilirubin
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Topics |
- Animals
- Apoptosis
- Bilirubin
(blood)
- Biliverdine
(therapeutic use)
- Blood Pressure
- Brain Death
- Enzyme-Linked Immunosorbent Assay
- In Situ Nick-End Labeling
- Inflammation
(pathology)
- Interleukin-8
(blood)
- Lung Transplantation
(methods, pathology, physiology)
- Male
- NF-kappa B
(metabolism)
- Peroxidase
(metabolism)
- Rats
- Rats, Wistar
- Specific Pathogen-Free Organisms
- Tracheostomy
- Tumor Necrosis Factor-alpha
(blood)
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