Abstract | BACKGROUND: OBJECTIVES: To assess whether magnesium maintenance therapy is effective in preventing preterm birth after the initial threatened preterm labour is arrested. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (May 2010). SELECTION CRITERIA: Randomised controlled trials of magnesium therapy given to women after threatened preterm labour. DATA COLLECTION AND ANALYSIS: The review authors independently assessed the studies for inclusion, assessed risk of bias and carried out data extraction. We checked data entry. MAIN RESULTS: We included four trials, which recruited 422 women. Three trials had high risk of bias and none included any long-term follow up of infants. No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies ( ritodrine or terbutaline). The risk ratio (RR) for preterm birth (less than 37 weeks) for magnesium compared with placebo or no treatment was 1.05, 95% confidence interval (CI) 0.80 to 1.40 (two trials, 99 women); and 0.99, 95% CI 0.57 to 1.72 (2 trials, 100 women) for magnesium compared with alternative therapies. The RR for perinatal mortality for magnesium compared with placebo or no treatment was 5.00, 95% CI 0.25 to 99.16 (one trial, 50 infants) and also compared with alternative treatments, was 5.00, 95% CI 0.25 to 99.16 (one trial, 50 infants). Women taking magnesium preparations were less likely to report palpitations or tachycardia than women receiving alternative therapies (RR 0.26, 95% CI 0.13 to 0.52, three trials, 237 women) but were much more likely to experience diarrhoea (RR 7.66, 95% CI 2.18 to 26.98, three trials, 237 women). AUTHORS' CONCLUSIONS:
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Authors | Shanshan Han, Caroline A Crowther, Vivienne Moore |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 7
Pg. CD000940
(Jul 07 2010)
ISSN: 1469-493X [Electronic] England |
PMID | 20614423
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Magnesium Compounds
- Tocolytic Agents
- Magnesium Chloride
- Magnesium Oxide
- Magnesium Sulfate
- Ritodrine
- Terbutaline
|
Topics |
- Female
- Humans
- Magnesium Chloride
(therapeutic use)
- Magnesium Compounds
(therapeutic use)
- Magnesium Oxide
(therapeutic use)
- Magnesium Sulfate
(therapeutic use)
- Obstetric Labor, Premature
(drug therapy)
- Pregnancy
- Premature Birth
(prevention & control)
- Randomized Controlled Trials as Topic
- Ritodrine
(therapeutic use)
- Terbutaline
(therapeutic use)
- Tocolysis
(methods)
- Tocolytic Agents
(therapeutic use)
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