Cyclosporine-responsive granulomatous sebaceous adenitis in a dog.

Abstract

Granulomatous sebaceous adenitis was diagnosed in a 2 year old spayed Miniature Pinscher. Initial treatment with isotretinoin for 3 weeks resulted in little response and decreased tear production. Immunosuppressive doses of prednisone for 3 weeks resulted in mild response of the dermatitis; however, the dog developed transient diabetes mellitus secondary to this treatment. Cyclosporine (5 mg/kg of body weight, po, q 12 h) resulted in good clinical response for 12 months, but histologically, the sebaceous glands remained absent. Although cyclosporine has immunosuppressive properties, this drug also has inhibitory effects of keratinocyte proliferation. These mechanisms may explain the beneficial response of cyclosporine in the treatment of granulomatous sebaceous adenitis in this dog.

• Authors: M A Carothers, K W Kwochka, J L Rojko
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 198 Issue 9 Pg. 1645-8 (May 01 1991) ISSN: 0003-1488 [Print] United States
• PMID: 2061184 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclosporins

Topics

• Animals
• Cyclosporins (therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Female
• Granuloma (drug therapy, veterinary)
• Lymphadenitis (drug therapy, veterinary)
• Sebaceous Glands
• Skin Diseases (drug therapy, veterinary)