Abstract | BACKGROUND: OBJECTIVE: DESIGN: We estimated the increase in ferritin associated with inflammation (ie, CRP gt 5 mg/L and/or AGP gt 1 g/L). The 32 studies comprised infants (5 studies), children (7 studies), men (4 studies), and women (16 studies) (n = 8796 subjects). In 2-group analyses (either CRP or AGP), we compared the ratios of log ferritin with or without inflammation in 30 studies. In addition, in 22 studies, the data allowed a comparison of ratios of log ferritin between 4 subgroups: reference (no elevated APP), incubation (elevated CRP only), early convalescence (both APP and CRP elevated), and late convalescence (elevated AGP only). RESULTS: In the 2-group analysis, inflammation increased ferritin by 49.6% (CRP) or 38.2% (AGP; both P lt 0.001). Elevated AGP was more common than CRP in young persons than in adults. In the 4-group analysis, ferritin was 30%, 90%, and 36% (all P lt 0.001) higher in the incubation, early convalescence, and late convalescence subgroups, respectively, with corresponding correction factors of 0.77, 0.53, and 0.75. Overall, inflammation increased ferritin by ap 30% and was associated with a 14% (CI: 7%, 21%) underestimation of ID. CONCLUSIONS: Measures of both APP and CRP are needed to estimate the full effect of inflammation and can be used to correct ferritin concentrations. Few differences were observed between age and sex subgroups.
|
Authors | David I Thurnham, Linda D McCabe, Sumanto Haldar, Frank T Wieringa, Christine A Northrop-Clewes, George P McCabe |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 92
Issue 3
Pg. 546-55
(Sep 2010)
ISSN: 1938-3207 [Electronic] United States |
PMID | 20610634
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- Orosomucoid
- C-Reactive Protein
- Ferritins
|
Topics |
- Adult
- Age Factors
- Anemia, Iron-Deficiency
(blood, complications, diagnosis)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Child
- Convalescence
- Female
- Ferritins
(blood)
- Humans
- Infant
- Infectious Disease Incubation Period
- Inflammation
(blood, complications)
- Male
- Orosomucoid
(metabolism)
|