Studies of the susceptibility of Pneumocystis carinii to clindamycin/primaquine in rats.

Abstract

Studies in rat models showed that the combination of primaquine plus clindamycin was effective in the therapy and prophylaxis of Pneumocystis carinii pneumonia and that the combination was more effective than either drug alone. These studies formed the basis of ongoing clinical therapy studies and provide a basis for clinical studies of prophylactic efficacy.

• Authors: J W Smith
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 10 Issue 3 Pg. 201-3 (Mar 1991) ISSN: 0934-9723 [Print] Germany
• PMID: 2060531 (Publication Type: Journal Article)

Chemical References

• Clindamycin
• Primaquine

Topics

• Animals
• Clindamycin (pharmacology)
• Immune Tolerance
• Microbial Sensitivity Tests
• Pneumocystis (drug effects, growth & development)
• Primaquine (pharmacology)
• Rats