Valproic acid as a therapy for adenomyosis: a comparative case series.

Adenomyosis is a difficult disease to manage and currently there is no investigative drug for adenomyosis on the horizon. We have previously reported in a pilot study that valproic acid (VPA) appears to be effective in treating adenomyosis. In this case series, we further evaluated the efficacy of VPA, with or without a progestin-containing intrauterine device, in the treatment of patients with adenomyosis. We recruited 12 patients with confirmed adenomyosis who complained of dysmenorrehea and had enlarged uterus. All patients took VPA for 3 months, then randomly assigned to 2 groups, 1 receiving no further treatment and the other were inserted with a levonorgestrel-releasing intrauterine system (Mirena) and were followed up for an additional 3 months. The primary outcome measures were the severity of dysmenorrhea and uterine size. Both measures were evaluated prior to the drug treatment and 3 and 6 months after the drug treatment, respectively. We found that VPA treatment resulted in complete resolution of dysmenorrhea and an average reduction in uterine size by 26% 6 months after the treatment, regardless of whether Mirena was used or not. Moreover, the amount of menses decreased significantly. Thus, VPA appears to be well tolerated and a promising drug for treating adenomyosis.
Authors Xishi Liu, Lei Yuan, Sun-Wei Guo
JournalReproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 17 Issue 10 Pg. 904-12 (Oct 2010) ISSN: 1933-7205 [Electronic] United States
PMID20601534 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Levonorgestrel
  • Valproic Acid
  • Adult
  • Dysmenorrhea (drug therapy)
  • Endometriosis (drug therapy)
  • Female
  • Humans
  • Intrauterine Devices, Medicated
  • Levonorgestrel (administration & dosage)
  • Organ Size
  • Pain Measurement
  • Random Allocation
  • Uterus (drug effects)
  • Valproic Acid (therapeutic use)

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