Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake.

Abstract

The objective of this study was to clarify the role of a novel agonist with high selectivity and affinity for Y4 receptors in the regulation of food intake. The Y4 receptor agonist BVD-74D was administered to C57BL/6J mice that were fed with a normal or high-fat diet, and to fatty liver Shionogi (FLS)-ob/ob mice; the food intake, water intake, and body weight gain were measured in these mice. In the mice fed with a normal diet, the cumulative food intake significantly decreased at 20 min and 1 h after the administration of 1 mg/kg of BVD-74D and at 1, 2, 4, 8, and 24 h after the administration of 10 mg/kg of BVD-74D. Moreover, the cumulative water intake and body weight gain significantly decreased in these mice. Among the mice that were fed with a high-fat diet, the cumulative food intake and water intake significantly decreased 1, 2, and 4 h after BVD-74D (10 mg/kg) administration. Furthermore, the cumulative food intake significantly decreased 2 and 4 h after BVD-74D (10 mg/kg) administration in the FLS-ob/ob mice. Thus, we propose that the novel Y4 receptor agonist BVD-74D has suppressive effects on food intake, water intake, and weight gain in normal mice fed with normal diets and on food intake in normal mice fed with high-fat diets and in FLS-ob/ob mice. These findings indicate that the Y4 receptor and its agonist would be promising targets for obesity.

• Authors: Jiang-Bo Li, Akihiro Asakawa, Mutsumi Terashi, KaiChun Cheng, Huhe Chaolu, Takahiro Zoshiki, Miharu Ushikai, Sulaiman Sheriff, Ambikaipakan Balasubramaniam, Akio Inui
• Journal: Peptides (Peptides) Vol. 31 Issue 9 Pg. 1706-10 (Sep 2010) ISSN: 1873-5169 [Electronic] United States
• PMID: 20600429 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Obesity Agents
• Appetite Depressants
• BVD-74D peptide
• Dietary Fats
• Peptides
• Receptors, Neuropeptide Y
• neuropeptide Y4 receptor

Topics

• Animals
• Anti-Obesity Agents (adverse effects, therapeutic use)
• Anxiety (chemically induced)
• Appetite Depressants (adverse effects, therapeutic use)
• Appetite Regulation (drug effects)
• Behavior, Animal (drug effects)
• Dietary Fats (administration & dosage)
• Dose-Response Relationship, Drug
• Drinking (drug effects)
• Fatty Liver (drug therapy)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Obese
• Obesity (drug therapy)
• Peptides (adverse effects, therapeutic use)
• Receptors, Neuropeptide Y (agonists)
• Time Factors
• Weight Gain (drug effects)