Abstract | BACKGROUND: MATERIAL AND METHODS: Specific IgG antibodies against goose and duck feathers, analysed with an automated fluorimetric enzyme immunoassay, were measured in healthy subjects (group A, n = 30), in patients with FDL (group B, n = 10) and with BFL (group C, n = 35); typical specific IgG antibodies of BFL in groups B and C. RESULTS: An optimal threshold value for antibodies against goose or duck feathers to differentiate patients with either BFL or FDL from healthy subjects was determined at 10.85 mg L(-1) for goose feathers and at 8.81 mg L(-1) for duck feathers, respectively. Specific IgG antibodies against goose feathers were significantly higher in group B compared with group C. A ratio of specific IgG antibodies against goose feathers and budgerigar antigens with a threshold value of 0.91 could discriminate between patients with FDL and BFL with a specificity of 97% and a sensitivity of 90%. CONCLUSIONS:
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Authors | Dirk Koschel, Lars Lützkendorf, Bärbel Wiedemann, Gert Höffken |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 40
Issue 9
Pg. 797-802
(Sep 2010)
ISSN: 1365-2362 [Electronic] England |
PMID | 20597960
(Publication Type: Journal Article)
|
Chemical References |
- Antigens
- Immunoglobulin G
|
Topics |
- Alveolitis, Extrinsic Allergic
(immunology)
- Animals
- Antibody Specificity
(immunology)
- Antigens
(blood, immunology)
- Bedding and Linens
- Bird Fancier's Lung
(immunology)
- Columbidae
(immunology)
- Ducks
(immunology)
- Feathers
(immunology)
- Fluorometry
- Geese
(immunology)
- Humans
- Immunoglobulin G
(blood, immunology)
- Melopsittacus
(immunology)
- Parrots
(immunology)
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