Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases.

Abstract

Sinonasal inverted papilloma (IP) is a primary benign lesion with a tendency for local recurrence. Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface protrusions and cell motility. Fascin up-regulation in lung, gastric, breast and hepatobiliary carcinomas correlates with aggressiveness and decreased survival. Here we evaluate immunohistochemical expression of fascin in 47 sinonasal IPs from 34 patients. Fascin over-expression is significantly more common in sinonasal IP with high-grade dysplasia than in those with no dysplastic or low-grade dysplastic epithelium (P = 0.0001). No significant change in fascin expression is seen with recurrence. Over expression of fascin in high-grade dysplastic epithelium in IP may be associated with tumor progression and malignant transformation.

• Authors: Hope H Wu, Samiah Zafar, Youming Huan, Herman Yee, Luis Chiriboga, Beverly Y Wang
• Journal: Head and neck pathology (Head Neck Pathol) Vol. 3 Issue 3 Pg. 212-6 (Sep 2009) ISSN: 1936-0568 [Electronic] United States
• PMID: 20596974 (Publication Type: Journal Article)

Chemical References

• Carrier Proteins
• Microfilament Proteins
• fascin

Topics

• Adult
• Aged
• Aged, 80 and over
• Carrier Proteins (biosynthesis)
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Male
• Microfilament Proteins (biosynthesis)
• Middle Aged
• Nose Neoplasms (metabolism, pathology)
• Papilloma, Inverted (metabolism, pathology)
• Up-Regulation
• Young Adult