Abstract | AIMS: Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. METHODS: Families with two or more siblings with type 2 diabetes and their nondiabetic siblings were studied as part of the Diabetes Heart Study (DHS). European American diabetic (n = 828) and nondiabetic (n = 170) siblings were genotyped for SNPs in the ALOX12, ALOX15, ALOX5, and ALOX5AP genes. Subclinical measures of atherosclerosis (IMT, coronary (CorCP), carotid (CarCP) and aortic (AorCP) calcified plaque) were obtained. RESULTS: Associations were observed between ALOX12 with CorCP, ALOX5 with CorCP, AorCP, and IMT, and ALOX5AP with CorCP and CarCP, independent of known epidemiologic risk factors. Further, lipoxygenase pathway SNPs that were associated with measures of atherosclerosis were associated with markers of inflammation (CRP, ICAM-1) and calcification (MGP). CONCLUSIONS:
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Authors | Kathryn P Burdon, Megan E Rudock, Allison B Lehtinen, Carl D Langefeld, Donald W Bowden, Thomas C Register, Yongmei Liu, Barry I Freedman, J Jeffrey Carr, Catherine C Hedrick, Stephen S Rich |
Journal | Mediators of inflammation
(Mediators Inflamm)
Vol. 2010
Pg. 170153
( 2010)
ISSN: 1466-1861 [Electronic] United States |
PMID | 20592751
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Isoenzymes
- Arachidonate 5-Lipoxygenase
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Topics |
- Aged
- Animals
- Arachidonate 5-Lipoxygenase
(genetics, metabolism)
- Atherosclerosis
(genetics, pathology, physiopathology)
- Biomarkers
(metabolism)
- Diabetes Mellitus, Type 2
(pathology, physiopathology)
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans
- Isoenzymes
(genetics, metabolism)
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
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