Acetogenic fibers reduce fasting glucose turnover but not peripheral insulin resistance in metabolic syndrome patients.

Abstract

BACKGROUND & AIMS:

The acute ingestion of an acetogenic indigestible carbohydrate (lactulose) increased acetate turnover associated with decreased lipolysis (glycerol turnover) in insulin-resistant patients. It is not known whether a decreased lipolysis by chronic ingestion of acetogenic indigestible carbohydrates or fibers improves glucose turnover and insulin sensitivity.

METHODS:

Twenty-one men with metabolic syndrome ingested daily standardized drinks, with or without 28 g acetogenic fibers (acacia gum and pectin), for 5 weeks in a randomized double-blind crossover controlled study design. Euglycaemic-hyperinsulinaemic (EH) clamps coupled with kinetic studies were performed in the fasting state after treatments.

RESULTS:

Flatulence was more frequent with fiber treatment. Body weight, lipids as well as acetate and glycerol turnovers were unchanged. Fasting endogenous glucose turnover was improved after fiber treatment (7.9 ± 1.3 μmol kg(-1) min(-1)) compared with control (8.6 ± 1.6 μmol kg(-1) min(-1), P < 0.05). But insulin sensitivity (glucose infusion rate) during the EH clamp was not different at the end of fiber and control treatments, 3.7 ± 1.8 and 3.8 ± 1.5 mg kg(-1) min(-1), respectively, nor fasting plasma glucose and insulin.

CONCLUSIONS:

The chronic ingestion of acacia gum and pectin fibers did not decrease lipolysis but improved fasting endogenous glucose turnover with no effect on peripheral insulin resistance in metabolic syndrome patients.

• Authors: Etienne Pouteau, Véronique Ferchaud-Roucher, Yassine Zair, Morine Paintin, Marc Enslen, Nicolas Auriou, Katherine Macé, Jean-Philippe Godin, Olivier Ballèvre, Michel Krempf
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 29 Issue 6 Pg. 801-7 (Dec 2010) ISSN: 1532-1983 [Electronic] England
• PMID: 20584565 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2010. Published by Elsevier Ltd.

Chemical References

• Acetogenins
• Blood Glucose
• Insulin
• Gum Arabic

Topics

• Acetogenins (metabolism)
• Adipose Tissue (metabolism)
• Adult
• Blood Glucose (metabolism)
• Cross-Over Studies
• Double-Blind Method
• Fasting
• Glucose Clamp Technique
• Gum Arabic (metabolism)
• Humans
• Insulin (blood)
• Insulin Resistance
• Lipolysis
• Male
• Metabolic Syndrome (metabolism)
• Middle Aged
• Young Adult