Abstract |
The ability of rabies virus ribonucleoprotein (RNP) to induce protective immunity against rabies and to prime for production of virus- neutralizing antibodies (VNA) was studied in monkeys. Following two immunizations with RNP, monkeys developed a strong anti-RNP response and were protected against a challenge infection with a lethal dose of street rabies virus. Monkeys that were primed with RNP and then immunized with a single dose of human diploid cell vaccine (HDCV) developed VNA titres comparable to the VNA titres in non-primed monkeys after a second HDCV immunization. The utility of rabies RNP for the pre-exposure prophylaxis of human rabies is discussed.
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Authors | M Tollis, B Dietzschold, C B Volia, H Koprowski |
Journal | Vaccine
(Vaccine)
Vol. 9
Issue 2
Pg. 134-6
(Feb 1991)
ISSN: 0264-410X [Print] Netherlands |
PMID | 2058261
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Viral
- Rabies Vaccines
- Ribonucleoproteins
- Vaccines, Synthetic
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Topics |
- Animals
- Antibodies, Viral
(biosynthesis)
- Macaca fascicularis
- Neutralization Tests
- Rabies
(prevention & control)
- Rabies Vaccines
(administration & dosage, isolation & purification)
- Rabies virus
(immunology)
- Ribonucleoproteins
(immunology)
- Vaccines, Synthetic
(administration & dosage, isolation & purification)
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