Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension.

Abstract

AIM:

The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH).

METHODS:

Ten T2D patients (age: 53.6±1.3 years; body mass index: 30.6±1.0kg/m(2); resting blood glucose: 157.8±40.2mgdL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5±1.0 years; body mass index: 28.3±0.9kg/m(2); resting blood glucose: 91.2±10.5mgdL(-1)) underwent two experimental sessions, consisting of 20min of rest plus 20min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3AC1-1 monitor) and PKA were measured during rest and every 15min for 135min of the postexercise recovery period (RP).

RESULTS:

During the RP, the ND individuals presented with PEH at 30, 45 and 120min (P<0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15min postexercise in the ND (P<0.05), but not in the T2D patients.

CONCLUSION:

T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH.

• Authors: D F Motta, L C J Lima, G Arsa, P S Russo, M M Sales, S R Moreira, P K Morais, W S Almeida, R C Araujo, M R Moraes, J L Pesquero, H G Simões, C S G Campbell
• Journal: Diabetes & metabolism (Diabetes Metab) Vol. 36 Issue 5 Pg. 363-8 (Nov 2010) ISSN: 1878-1780 [Electronic] France
• PMID: 20579916 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Kallikreins

Topics

• Blood Pressure (physiology)
• Diabetes Mellitus, Type 2 (blood, complications)
• Exercise (physiology)
• Female
• Humans
• Hypotension (etiology)
• Kallikreins (blood)
• Kinetics
• Male
• Middle Aged