[Intravitreal bevacizumab in the treatment of neovascular glaucoma].

Abstract

PURPOSE:

To report the effect of an intravitreal injection of 1.25 mg (0.05 ml) of bevacizumab (IVB) as symptomatic treatment for neovascular glaucoma.

PATIENTS AND METHOD:

This prospective study included 13 eyes of 12 patients presenting neovascular glaucoma, in two cases secondary to ischemic central retinal vein occlusion and, in ten cases, to proliferative diabetic retinopathy. Each patient received an intravitreal injection of 1.25 mg (0.05 ml) of bevacizumab, in combination with other procedures such as panretinal photocoagulation to treat retinal ischemia and transscleral cyclocryoapplication as glaucoma treatment. Their mean age was 58 years (range, 35-75 years). The mean intraocular pressure (IOP) was 40 mmHg+/-10 mmHg. The mean follow-up was 6 months.

RESULTS:

IVB resulted in a marked regression of anterior segment neovascularization and relief of symptoms within 48 h. IOP decreased substantially in eight eyes; in four eyes, adjuvant cyclocryoapplication was necessary. The last eye was affected by a retinal detachment 1 month after IVB. No side effects were observed.

DISCUSSION:

We observed that the intravitreal injection of bevacizumab enabled the total regression of iris and angle neovascularization but had only a partial action on intraocular hypertension.

CONCLUSION:

Intravitreal injection of 1.25 mg (0.05 ml) of bevacizumab contributes to a better management of neovascular glaucoma.

• Authors: O Ouhadj, I Chergui, L Mendil, M T Nouri
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 32 Issue 2 Pg. 112-6 (Feb 2009) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Injection intravitréenne de Bevacizumab (Avastin) dans le traitement du glaucome néovasculaire.
• PMID: 20579473 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Bevacizumab

Topics

• Adult
• Aged
• Angiogenesis Inhibitors (administration & dosage)
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Bevacizumab
• Female
• Glaucoma, Neovascular (drug therapy)
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Prospective Studies