Abstract | BACKGROUND: The objective of this study was to investigate the effects of a protein-rich diet in comparison with a conventional protein diet on weight loss, weight maintenance, and body composition in subjects with the metabolic syndrome. METHODS: Obese subjects received instructions for an energy-restricted diet with a calorie deficit of 500 kcal/day and were randomly assigned to either high- protein (1.34 g/kg body weight) or conventional protein (0.8 g/kg body weight) diets for 12 months. Protein-enriched meal replacements were used to enrich one arm of the diet with protein throughout the study. In all, 67% of the participants completed the 1-year study. RESULTS: Subjects following the high-protein diet lost more body weight and more fat mass compared with those on the conventional protein diet, whereas the loss of fat-free mass was similar in both diet groups. Biochemical parameters associated with the metabolic syndrome improved in both diet groups. Improvements were modestly greater in subjects with the high-protein diet. After 12 months of treatment, 64.5% of the subjects in the high-protein diet group and 34.8% of the subjects in the conventional diet group no longer met three or more of the criteria for having the metabolic syndrome. CONCLUSIONS:
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Authors | Marion Flechtner-Mors, Bernhard O Boehm, Regina Wittmann, Ulrike Thoma, Herwig H Ditschuneit |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 26
Issue 5
Pg. 393-405
(Jul 2010)
ISSN: 1520-7560 [Electronic] England |
PMID | 20578205
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2010 John Wiley & Sons, Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Body Composition
(drug effects)
- Diet, Reducing
(methods)
- Dietary Proteins
(administration & dosage)
- Energy Intake
- Female
- Humans
- Male
- Metabolic Syndrome
(diet therapy)
- Middle Aged
- Obesity
(diet therapy)
- Weight Loss
(drug effects)
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