Abstract | OBJECTIVE: To determine risk factors and adverse perinatal outcomes including nutritional status in the first week of life for newborns with intrauterine growth restriction-low birth weight (IUGR-LBW) in settings lacking facilities for routine intrauterine growth monitoring. METHODS: A cross-sectional study of all infants in an inner-city hospital in Lagos, Nigeria. IUGR-LBW was defined as full-term (gestational age> or =37 weeks) infant with low birth weight (<2500g). Nutritional/growth status at enrolment was determined by z-scores for length-for-age (HAZ), head circumference-for-age (HCZ), weight-for-age (WAZ) and weight-for-length (WHZ) based on current World Health Organization's Multicentre Growth Reference (WHO-MGR). Factors and adverse outcomes associated with IUGR-LBW were explored with multivariable logistic regression analyses. RESULTS: Some 145 (4.3%) infants were IUGR-LBW out of 2619 eligible singletons enlisted for this study. IUGR-LBW was significantly associated with teenage mothers (OR:2.90, 95% CI:1.22-6.89), lack of antenatal care (OR:1.88, 95% CI:1.33-2.65) and female gender (OR:1.38, 95% CI: 0.98-1.93; p=0.062). The incidence of adverse outcomes across gestational age showed significant linear trend only for low five-minute Apgar scores (p=0.024) and WAZ (p=0.065). IUGR-LBW was associated with poor nutritional status across all four indices (p<0.001) as well as low 5-minute Apgar scores (p=0.095), sepsis (p=0.053), hyperbilirubinemia (p<0.001) and admission into special care baby unit (p=0.009) after multivariable logistic regression analyses. CONCLUSIONS: IUGR-LBW correlates with poor nutritional status in the first week of life based on WHO-MGR and affected infants can be detected early for effective surveillance in resource-poor settings. Improved prenatal care among teenage mothers is necessary for reducing IUGR-LBW burden.
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Authors | Bolajoko O Olusanya |
Journal | Early human development
(Early Hum Dev)
Vol. 86
Issue 7
Pg. 439-44
(Jul 2010)
ISSN: 1872-6232 [Electronic] Ireland |
PMID | 20576369
(Publication Type: Journal Article)
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Copyright | 2010 Elsevier Ltd. All rights reserved. |
Topics |
- Apgar Score
- Body Size
- Cross-Sectional Studies
- Female
- Fetal Growth Retardation
(epidemiology, pathology)
- Gestational Age
- Humans
- Infant, Low Birth Weight
(growth & development)
- Infant, Newborn
- Nigeria
- Nutritional Status
- Pregnancy
- Prenatal Care
- Risk Factors
- World Health Organization
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