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Intrauterine growth restriction in a low-income country: Risk factors, adverse perinatal outcomes and correlation with current WHO Multicenter Growth Reference.

AbstractOBJECTIVE:
To determine risk factors and adverse perinatal outcomes including nutritional status in the first week of life for newborns with intrauterine growth restriction-low birth weight (IUGR-LBW) in settings lacking facilities for routine intrauterine growth monitoring.
METHODS:
A cross-sectional study of all infants in an inner-city hospital in Lagos, Nigeria. IUGR-LBW was defined as full-term (gestational age> or =37 weeks) infant with low birth weight (<2500g). Nutritional/growth status at enrolment was determined by z-scores for length-for-age (HAZ), head circumference-for-age (HCZ), weight-for-age (WAZ) and weight-for-length (WHZ) based on current World Health Organization's Multicentre Growth Reference (WHO-MGR). Factors and adverse outcomes associated with IUGR-LBW were explored with multivariable logistic regression analyses.
RESULTS:
Some 145 (4.3%) infants were IUGR-LBW out of 2619 eligible singletons enlisted for this study. IUGR-LBW was significantly associated with teenage mothers (OR:2.90, 95% CI:1.22-6.89), lack of antenatal care (OR:1.88, 95% CI:1.33-2.65) and female gender (OR:1.38, 95% CI: 0.98-1.93; p=0.062). The incidence of adverse outcomes across gestational age showed significant linear trend only for low five-minute Apgar scores (p=0.024) and WAZ (p=0.065). IUGR-LBW was associated with poor nutritional status across all four indices (p<0.001) as well as low 5-minute Apgar scores (p=0.095), sepsis (p=0.053), hyperbilirubinemia (p<0.001) and admission into special care baby unit (p=0.009) after multivariable logistic regression analyses.
CONCLUSIONS:
IUGR-LBW correlates with poor nutritional status in the first week of life based on WHO-MGR and affected infants can be detected early for effective surveillance in resource-poor settings. Improved prenatal care among teenage mothers is necessary for reducing IUGR-LBW burden.
AuthorsBolajoko O Olusanya
JournalEarly human development (Early Hum Dev) Vol. 86 Issue 7 Pg. 439-44 (Jul 2010) ISSN: 1872-6232 [Electronic] Ireland
PMID20576369 (Publication Type: Journal Article)
Copyright2010 Elsevier Ltd. All rights reserved.
Topics
  • Apgar Score
  • Body Size
  • Cross-Sectional Studies
  • Female
  • Fetal Growth Retardation (epidemiology, pathology)
  • Gestational Age
  • Humans
  • Infant, Low Birth Weight (growth & development)
  • Infant, Newborn
  • Nigeria
  • Nutritional Status
  • Pregnancy
  • Prenatal Care
  • Risk Factors
  • World Health Organization

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