Abstract | OBJECTIVE: DESIGN: Observational study. SETTING: University hospital. PARTICIPANTS: Sixteen consecutive patients (10 men and 6 women) scheduled to undergo thoracoabdominal aortic aneurysm repair were enrolled in the study. All patients were affected by atherosclerotic aneurysmal pathology. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: During surgery, the authors simultaneously withdrew samples of cerebrospinal fluid and arterial blood to evaluate pO(2), pCO(2), pH, and lactate concentration. Samples were collected at 5 fixed times during and after surgery: T1 (before aortic cross-clamping), T2 (15 minutes after clamping), T3 (just before unclamping), T4 (end of surgery), and T5 (4 hours after the end of surgery). Lactate levels in cerebrospinal fluid rose consistently during aortic cross-clamping (T1 = 1.89 mmol/L, T2 = 2.21 mmol/L, T3 = 2.88 mmol/L, T4 = 3.655 mmol/L, and T5 = 3.16 mmol/L). Lactate concentrations in the cerebrospinal fluid were significantly higher in the 4 patients who developed neurologic injury, even at T1 (before surgery), than in those who did not end in spinal cord injury with the 4 highest values belonging to the 4 patients who later developed spinal cord injury. CONCLUSIONS:
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Authors | Giuseppina Casiraghi, Davide Poli, Giovanni Landoni, Luca Buratti, Roberto Imberti, Valentina Plumari, Stefano Turi, Roberta Mennella, Melissa Messina, Remo Daniel Covello, Andrea Carozzo, Andrea Motta, Alberto Zangrillo |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 25
Issue 1
Pg. 120-6
(Feb 2011)
ISSN: 1532-8422 [Electronic] United States |
PMID | 20570182
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Anesthesia, General
- Aorta, Abdominal
(surgery)
- Aorta, Thoracic
(surgery)
- Aortic Aneurysm, Thoracic
(cerebrospinal fluid, surgery)
- Biomarkers
- Critical Care
- Disseminated Intravascular Coagulation
- Female
- Hemodynamics
(physiology)
- Humans
- Lactic Acid
(cerebrospinal fluid)
- Male
- Middle Aged
- Monitoring, Intraoperative
- Paraplegia
(etiology)
- Postoperative Complications
(cerebrospinal fluid, etiology)
- Preanesthetic Medication
- Predictive Value of Tests
- Shock, Septic
(etiology)
- Spinal Cord Injuries
(cerebrospinal fluid, etiology)
- Thoracotomy
- Vascular Surgical Procedures
(adverse effects)
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