[A case of hepatopulmonary syndrome with elevated exhaled nitric oxide].

Abstract

A 76-year-old man was admitted to our hospital because of dyspnea. Three years before admission, dyspnea was recognized and had been given a diagnosis of interstitial pneumonia by a general physician. A year later, he received home oxygen therapy. After admission, we found that he had alcoholic liver cirrhosis and an increased alveolar-arterial oxygen level in his arterial blood gas. Moreover, he had an intrapulmonary vascular shunt, detected by contrast-enhanced echocardiography and perfusion scan with 99mTc-macroaggregated albumin. These results confirmed hepatopulmonary syndrome. Furthermore, exhaled nitric oxide (NO) was elevated in the patient although he had never had bronchial asthma or any other allergic diseases. Animal models of hepatopulmonary syndrome have shown that exhaled NO is associated with dilated vessels. To the best of our knowledge, this paper describes the first case of hepatopulmonary syndrome with elevated exhaled NO in Japan.

• Authors: Junji Hamamoto, Satoshi Toba, Susumu Hirosako, Kazuyoshi Nakamura, Kazuhiko Fujii, Hirotsugu Kohrogi
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 48 Issue 5 Pg. 379-84 (May 2010) ISSN: 1343-3490 [Print] Japan
• PMID: 20560441 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Nitric Oxide

Topics

• Aged
• Breath Tests
• Hepatopulmonary Syndrome (physiopathology)
• Humans
• Male
• Nitric Oxide (analysis)