Abstract | BACKGROUND: HYPOTHESIS: We evaluated the long-term clinical outcomes of DES vs bare metal stents (BMS) in Chinese patients. METHODS: RESULTS: The 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (3.4%, 0.9%, 3.6%) when compared with the BMS group (7.5%, 4.4%, 6.2%; P < .05). No significant differences were found in the 3-year cumulative rates for TLR or stent thrombosis when comparing the DES group (8.3%, 1.63%) vs the BMS group (9.6%, 1.6%; P > .05). However, after 1 year, there were 8 episodes of stent thrombosis in the DES group vs 1 episode of stent thrombosis in the BMS group (P = .04). CONCLUSION:
Drug-eluting stents are associated with a significant reduction in the 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction when compared to BMS. However, there were no significant differences in the cumulative rates of TLR or stent thrombosis at 3 years. Stent thrombosis after 1 year was more common in the DES group, but this did not translate to increased mortality. The suggestion that DES might confer a mortality benefit should be interpreted with caution as there could be several confounding factors that were not identified in our study.
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Authors | Hee-Hwa Ho, Vincent Pong, Chung-Wah Siu, Man-Hong Jim, Raymond Miu, Kai-Hang Yiu, Ryan Ko, Hung-Fat Tse, On-Hing Kwok, Wing-Hing Chow |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 33
Issue 6
Pg. E22-9
(Jun 2010)
ISSN: 1932-8737 [Electronic] United States |
PMID | 20556818
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
(adverse effects, instrumentation, mortality)
- Asian People
(statistics & numerical data)
- China
- Coronary Angiography
- Coronary Artery Disease
(diagnostic imaging, ethnology, mortality, therapy)
- Drug-Eluting Stents
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Metals
- Middle Aged
- Myocardial Infarction
(ethnology)
- Proportional Hazards Models
- Registries
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Stents
- Thrombosis
(ethnology)
- Time Factors
- Treatment Outcome
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