Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy.

Abstract

In infants with hypoxic-ischemic encephalopathy, cooling reduces death/neurodevelopmental impairment, whereas prophylactic anticonvulsants may not. This retrospective analysis shows no reduction in neurodevelopmental impairment (23% in prophylactic phenobarbital group vs 45% in controls, P = .3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001).

• Authors: Donald F Meyn Jr, Jayne Ness, Namasivayam Ambalavanan, Waldemar A Carlo
• Journal: The Journal of pediatrics (J Pediatr) Vol. 157 Issue 2 Pg. 334-6 (Aug 2010) ISSN: 1097-6833 [Electronic] United States
• PMID: 20553847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 Mosby, Inc. All rights reserved.

Chemical References

• Anticonvulsants
• Excitatory Amino Acid Antagonists
• Phenobarbital

Topics

• Anticonvulsants (therapeutic use)
• Child, Preschool
• Cold Temperature
• Excitatory Amino Acid Antagonists (therapeutic use)
• Female
• Humans
• Hydrogen-Ion Concentration
• Hypothermia, Induced
• Hypoxia-Ischemia, Brain (prevention & control, therapy)
• Infant
• Male
• Phenobarbital (therapeutic use)
• Retrospective Studies
• Temperature
• Treatment Outcome