Abstract | INTRODUCTION: This case report demonstrates that the differential immunohistochemical reactivities of Siemens' Double Antibody Glucagon compared to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon allow for pathologic distinction of enteral versus pancreatic glucagonoma. CASE PRESENTATION: A 64-year-old Caucasian man was diagnosed with a duodenal enteroglucagonoma following presentation with obstructive jaundice. He had a low serum glucagon level using Siemens' Double Antibody Glucagon, a clinical syndrome consistent with glucagon hypersecretion. A periampullary mass biopsy proved to be a neuroendocrine tumor, with positive immunohistochemical reactivity to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon. CONCLUSIONS: Differential comparison of the immunohistochemical reactivities of Siemens' Double Antibody Glucagon and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon discerns enteroglucagon from pancreatic glucagon.
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Authors | Wesley B Vanderlan, Ziying Zhang, Marwan S Abouljoud |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 4
Pg. 178
(Jun 15 2010)
ISSN: 1752-1947 [Electronic] England |
PMID | 20550685
(Publication Type: Journal Article)
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