HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Angiographic evaluation of the effect of intra-arterial milrinone therapy in patients with vasospasm from aneurysmal subarachnoid hemorrhage.

AbstractINTRODUCTION:
Several methods have been used to treat cerebral vasospasm, which is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of milrinone for the treatment of vasospasm.
METHODS:
Consecutive patients with angiographically confirmed vasospasm received intra-arterial milrinone between January 2006 and December 2007. The improvement in diameter of vessel (in millimeters) following treatment was assessed by paired t test for statistical significance. The angiographic improvement of supraclinoid internal carotid artery, M1 segment of middle cerebral artery, and A1 and A2 segment of anterior cerebral artery was compared with the modified Rankin score of the patients at discharge.
RESULTS:
A total of 15 milrinone treatments were performed in 14 patients (11 females and 3 males) with mean age of 52.7 years (31-68 years). There was significant angiographic improvement after milrinone therapy (p < 0.0001).
CONCLUSION:
Intra-arterial milrinone was a safe and effective treatment of cerebral vasospasm following aneurysmal SAH.
AuthorsJai Jai Shiva Shankar, Marlise P dos Santos, Leonardo Deus-Silva, Cheemun Lum
JournalNeuroradiology (Neuroradiology) Vol. 53 Issue 2 Pg. 123-8 (Feb 2011) ISSN: 1432-1920 [Electronic] Germany
PMID20549498 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Vasodilator Agents
  • Milrinone
Topics
  • Adult
  • Aged
  • Cerebral Angiography (methods)
  • Female
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Milrinone (administration & dosage, adverse effects)
  • Subarachnoid Hemorrhage (complications, diagnostic imaging, drug therapy)
  • Treatment Outcome
  • Vasodilator Agents (administration & dosage, adverse effects)
  • Vasospasm, Intracranial (diagnostic imaging, drug therapy, etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: