HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes.

Abstract
The present study discusses the efficacy of Aloe emodin-8-O-glycoside (AEG), a plant derived anthroquinone, on alleviating insulin resistance and augmenting glycogen synthesis in L6 myotubes and 3T3L1 adipocytes. Dose-dependent increase in glucose uptake activity (GUA) was observed in both cell lines. Immunoblot analysis revealed an insulin-like glucose transporting mechanism of AEG by activating key markers involved in the insulin signaling cascade such as insulin receptor beta IRbeta, insulin receptor substrate1, 85 phosphatidyl inositol 3' kinase (PI3K) and PKB. Glucose transporter 4 translocation was confirmed by determining the uptake of glucose in the presence of insulin receptor tyrosine kinase and PI3K inhibitors. AEG was found to enhance glycogen synthesis through the inhibition of glycogen synthase kinase 3beta. In conclusion, AEG enhances glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen.
AuthorsS Anand, V S Muthusamy, S Sujatha, K N Sangeetha, R Bharathi Raja, S Sudhagar, N Poornima Devi, B S Lakshmi
JournalFEBS letters (FEBS Lett) Vol. 584 Issue 14 Pg. 3170-8 (Jul 16 2010) ISSN: 1873-3468 [Electronic] England
PMID20541550 (Publication Type: Journal Article)
CopyrightCopyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Glycosides
  • Insulin
  • Glycogen
  • Phosphatidylinositol 3-Kinases
  • Receptor, Insulin
  • Glycogen Synthase Kinases
  • Glucose
Topics
  • Adipocytes (metabolism)
  • Animals
  • Biological Transport
  • Carbohydrate Metabolism
  • Cell Differentiation (drug effects)
  • Glucose (metabolism)
  • Glycogen (metabolism)
  • Glycogen Synthase Kinases (metabolism)
  • Glycosides (metabolism)
  • Insulin (metabolism, pharmacology)
  • Insulin Resistance
  • Mice
  • Muscle Fibers, Skeletal
  • Phosphatidylinositol 3-Kinases (metabolism)
  • Receptor, Insulin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: