[Optimal combined use of rifampicin and immunomodulator of microbial origin in experimental Q-Rickettsia infection].

Abstract

Multifactorial analysis of the combined use of rifampicin and an immunomodulator of the microbial origin, such as peptidoglycan, was performed on a model of experimental Q fever in albino mice. On the basis of the experimental results, statistic polynomial models describing the weight of the murine spleens and the titers of the complement-binding antibodies were designed. It was shown that the action of the immunomodulator and antibiotic was highly synergistic with respect to the chemotherapeutic activity and antibody titers. The preventive use of the immunomodulator yielded a 30-fold decrease in a rifampicin therapeutic dose. The use of the immunomodulator also provided a pronounced immunomodulating effect with respect to humoral immunity. Nomographs for optimizing the dose-time parameters of the antibacterial and immunomodulating therapy were plotted.

• Authors: A V Nikitin, N D Klimchuk, I P Fomina, L P Ivanitskaia, V N Rozdobud'ko
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 36 Issue 1 Pg. 20-2 (Jan 1991) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Optimizatsiia kombinirovannogo primeneniia rifampitsina s immuno- moduliatorom mikrobnogo proiskhozhdeniia pri éksperimental'nom Ku-Rikketsioznoĭ infektsii.
• PMID: 2053816 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Peptidoglycan
• Rifampin

Topics

• Adjuvants, Immunologic (administration & dosage)
• Animals
• Disease Models, Animal
• Drug Synergism
• Drug Therapy, Combination
• Immune Tolerance (drug effects, immunology)
• Mice
• Peptidoglycan (administration & dosage)
• Q Fever (drug therapy, immunology)
• Rifampin (administration & dosage)