[Effect of Lycium barbarum polysaccharides on neurogenesis and learning & memory in manganese poisoning mice].

Abstract

OBJECTIVE:

To study the effect of Lycium barbarum polysaccharides (LBP) on neurogenesis and learning & memory of manganese poisoning mice.

METHODS:

Healthy adult Kunming mice were divided into 5 groups, the control group (A), the manganese poisoning (by manganese chloride peritoneal injection) group (B), the manganese poisoning and treated with gastric perfusion of high, medium, low dosage LBP groups (C, D and E). The spatial learning & memory capacity of mouse was determined by Morris water maze training test. The neurogenetic cells were labelled with bromodeoxyuridine (BrdU) and detected by immunohistochemistry.

RESULTS:

The average escape latency was significantly higher and the times of passing through platform lower in group B than those in group A (P<0.05). BrdU positive cells in groups C, D and E were significantly more than those in group B (P<0.05).

CONCLUSION:

LBP could enhance the learning & memory capability of the manganese poisoning mice by promoting neurogenesis in hippocampus.

• Authors: Jing Wen, Bo-ning Yang, Dan Ren
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 30 Issue 3 Pg. 295-8 (Mar 2010) ISSN: 1003-5370 [Print] China
• PMID: 20535931 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drugs, Chinese Herbal
• lycium barbarum polysaccharide

Topics

• Animals
• Drugs, Chinese Herbal (pharmacology)
• Learning (drug effects)
• Male
• Manganese Poisoning
• Memory (drug effects)
• Mice
• Mice, Inbred Strains
• Neurogenesis (drug effects)