Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis.

Abstract

PURPOSE:

The purpose of this study was to compare the efficacy of olopatadine with fluorometholone in contact lens-induced mild to moderate papillary conjunctivitis.

METHODS:

A randomized, double-masked study was conducted. Eighty-five (n = 170 eyes) soft contact lens users with mild to moderate papillary conjunctivitis were enrolled. Patients were randomly assigned to three groups to receive olopatadine 0.1%, fluorometholone 0.1%, or both. All drugs were instilled twice daily for 8 weeks. Contact lens use was discontinued during initial 4 weeks of therapy and subsequently patients were prescribed monthly disposable lenses. Patients were followed up every 2 weeks, and variables assessed were symptoms and signs, tear film status, and intraocular pressures.

RESULTS:

Decrease in ocular redness, itching, and tearing along with improvement in contact lens tolerance was comparable in all the three groups. Olopatadine was more effective in reducing redness than fluorometholone at 8 weeks (P=0.01). Improvement in congestion and papillary reaction was comparable in all groups. There was a significant increase in tear break up time of more than 2 sec for fluorometholone and no significant increase for olopatadine. The olopatadine and fluorometholone groups had significant increase of more than 2 mm in Schirmer test and more than 3 sec in tear break up time. In patients with subnormal and borderline tear functions, significant improvement was observed with both drugs. After 8 weeks of use of fluorometholone, there was a significant increase in intraocular pressure (P=0.003).

CONCLUSIONS:

Olopatadine and fluorometholone were the most effective for papillary conjunctivitis followed by olopatadine monotherapy and then fluorometholone monotherapy. Olopatadine is effective in alleviating signs and symptoms of contact lens-induced mild to moderate papillary conjunctivitis and is comparable with fluorometholone in efficacy.

• Authors: Saurbhi Khurana, Namrata Sharma, Tushar Agarwal, Bhavna Chawla, T Velpandian, Radhika Tandon, Jeewan S Titiyal
• Journal: Eye & contact lens (Eye Contact Lens) Vol. 36 Issue 4 Pg. 210-4 (Jul 2010) ISSN: 1542-233X [Electronic] United States
• PMID: 20531202 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Allergic Agents
• Dibenzoxepins
• Ophthalmic Solutions
• Olopatadine Hydrochloride
• Fluorometholone

Topics

• Anti-Allergic Agents (administration & dosage, therapeutic use)
• Conjunctiva (drug effects, pathology)
• Conjunctivitis, Allergic (diagnosis, drug therapy, etiology)
• Contact Lenses (adverse effects)
• Diagnosis, Differential
• Dibenzoxepins (administration & dosage, therapeutic use)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Fluorometholone (administration & dosage, therapeutic use)
• Follow-Up Studies
• Humans
• Male
• Olopatadine Hydrochloride
• Ophthalmic Solutions
• Severity of Illness Index
• Treatment Outcome
• Young Adult