Distribution of CCR5-{delta}32, CCR2-64I, and SDF1-3'A in Guangxi Zhuang population.

Abstract

BACKGROUND:

To investigate the distribution of CCR5-Delta32, CCR2-64I, and SDF1-3'A alleles in Guangxi province Zhuang population.

METHOD:

A total of 180 healthy individuals and 150 HIV-positive patients were recruited. All individuals were genotyped for CCR5 polymorphism using polymerase chain reaction (PCR), and CCR2 and SDF1 polymorphism using PCR restriction fragment length polymorphisms (PCR-RFLPs).

RESULTS:

No CCR5-Delta32 mutation was found. CCR2-64I frequency was 24.7% in the healthy group and 20.3% in the HIV-positive group, and SDF1-3'A was 30.6% and 29.3% in the 2 groups, respectively. There were no significances in the frequencies of CCR2-64I (chi(2) = 1.795, P = .180) and SDF1-3'A (chi(2) = 0.116, P = .733) between the 2 groups.

CONCLUSIONS:

The protective CCR5-Delta32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3'A are relatively common and seem not to confer protection against HIV-1 infection. The results suggest that the Zhuang people may have a similar genetic susceptibility to HIV-1 infection with most other Chinese ethnic groups.

• Authors: Qijian Su, Zhidan Mai, Ning Zang, Shuzhi Wu, Xin Xiao, Hao Liang
• Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) (J Int Assoc Physicians AIDS Care (Chic)) 2010 May-Jun Vol. 9 Issue 3 Pg. 145-9 ISSN: 1545-1097 [Print] United States
• PMID: 20530467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCR2 protein, human
• Chemokine CXCL12
• Receptors, CCR2
• Receptors, CCR5

Topics

• Adolescent
• Adult
• Case-Control Studies
• Chemokine CXCL12 (genetics)
• China (epidemiology)
• Female
• Gene Frequency
• Genotype
• HIV Infections (epidemiology, genetics)
• Heterozygote
• Homozygote
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Receptors, CCR2 (genetics)
• Receptors, CCR5 (genetics)
• Young Adult