Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod.

Abstract	The major purpose of this study was to determine the effects of procyanidins extracted from the lotus seedpod on cAMP-response element-binding protein phosphorylation in hippocampus and cerebral cortex in cognitively impaired aged rats. Based on Morris water maze, aged unimpaired and aged impaired rats were chosen from aged rats. Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. These results suggested that lotus seedpod might enhance cAMP-response element-binding-dependent transcription through the activation of extracellular signal-related kinase signalling pathway, which might contribute to its ameliorative effects on cognitive deficits in aged impaired animals.
Authors	Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Qianchun Deng, Hailei Wu, Wei Bao, Di Wang, Ping Yao, Fenghong Huang, Liegang Liu
Journal	The journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci) Vol. 65 Issue 9 Pg. 933-40 (Sep 2010) ISSN: 1758-535X [Electronic] United States
PMID	20530246 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Brain-Derived Neurotrophic Factor Plant Extracts Proanthocyanidins RNA, Messenger CREB-Binding Protein Crebbp protein, rat Protein Kinase C-alpha Calcium-Calmodulin-Dependent Protein Kinase Type 4 Extracellular Signal-Regulated MAP Kinases
Topics	Aging Animals Brain-Derived Neurotrophic Factor (metabolism) CREB-Binding Protein (metabolism) Calcium-Calmodulin-Dependent Protein Kinase Type 4 (metabolism) Cerebral Cortex (metabolism) Cognition Disorders (complications) Extracellular Signal-Regulated MAP Kinases (metabolism) Female Hippocampus (metabolism) Lotus Maze Learning Memory Disorders (drug therapy) Phosphorylation Plant Extracts (pharmacology) Proanthocyanidins (pharmacology) Protein Kinase C-alpha (metabolism) RNA, Messenger Rats Rats, Sprague-Dawley

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