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Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy - a preliminary study.

AbstractPURPOSE:
Data from the literature suggest that long-term therapy with various antiepileptic drugs can be responsible for the functional disturbances within the nervous system e.g. peripheral neuropathy and encephalopathy. Useful and non-invasive instruments for evaluation of even subclinical nerve conduction abnormalities in somatosensory tracts are somatosensory evoked potentials (SEPs). The aim of this study was to assess the potentially drug-induced abnormalities in the SEP parameters in epileptic children, treated chronically in monotherapy with one of the two most often used antiepileptic drugs: valproate (VPA) or carbamazepine (CBZ).
MATERIALS AND METHODS:
SEP from left median nerve stimulation were recorded in twenty children with idiopathic/cryptogenic epilepsy treated in monotherapy with CBZ (9 patients) or VPA (11 patients). The mean age of the patients was 13.4 ± 2.9 years (range 7-17 years). The plasma concentrations of the drugs were consistently within therapeutic range. The mean duration of treatment was eight months. The control group consisted of twenty-four age-matched children with tension type headache. The latencies of the components: N9, N13, N20, P25 and the peripheral conduction time (PCT) and central conduction time (CCT) were analyzed.
RESULTS:
No significant differences in all analyzed SEP parameters between the epileptic and control children were found.
CONCLUSIONS:
Our results indicate that during the first 8 months from the beginning of antiepileptic treatment in children, monotherapy with VPA or CBZ does not induce nerve conduction disturbances within both the peripheral- and the central part of the somatosensory tracts, detected in SEP examination.
AuthorsK Sendrowski, W Sobaniec, L Boćkowski, W Kułak, J Smigielska-Kuzia
JournalAdvances in medical sciences (Adv Med Sci) Vol. 55 Issue 2 Pg. 212-5 ( 2010) ISSN: 1898-4002 [Electronic] Poland
PMID20513644 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Carbamazepine
  • Valproic Acid
Topics
  • Adolescent
  • Anticonvulsants (adverse effects, therapeutic use)
  • Carbamazepine (adverse effects, therapeutic use)
  • Child
  • Epilepsy (drug therapy, physiopathology)
  • Evoked Potentials, Somatosensory (drug effects)
  • Female
  • Humans
  • Male
  • Valproic Acid (adverse effects, therapeutic use)

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