Abstract | BACKGROUND: PATIENTS AND METHODS: We identified patients with relapsed or refractory DLBCL at Weill Cornell Medical Center for whom data on responses to second-line chemotherapy were available. RESULTS: A total of 74 patients with relapsed or refractory DLBCL who underwent second-line chemotherapy between 1996 and 2007 were identified. Of these patients, 27 (36%) did not respond. The median overall survival of nonresponding patients was 4 months, and only 1 patient (4%) survived for 1 year. The choice of third-line aggressive chemotherapy instead of less intensive approaches did not confer a survival benefit. CONCLUSION: Our data demonstrate that patients with recurrent DLBCL not responding to second-line chemotherapy demonstrate dismal outcomes. Trials of novel regimens should be prioritized as management strategies for these patients. Our data provide an important benchmark in the evaluation of the potential clinical value of such approaches.
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Authors | Rebecca L Elstrom, Peter Martin, Katya Ostrow, Jacqueline Barrientos, Amy Chadburn, Richard Furman, Jia Ruan, Tsiporah Shore, Michael Schuster, Leandro Cerchietti, Ari Melnick, Morton Coleman, John P Leonard |
Journal | Clinical lymphoma, myeloma & leukemia
(Clin Lymphoma Myeloma Leuk)
Vol. 10
Issue 3
Pg. 192-6
(Jun 2010)
ISSN: 2152-2669 [Electronic] United States |
PMID | 20511164
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Lymphoma, Large B-Cell, Diffuse
(drug therapy, mortality, surgery)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(mortality, surgery)
- Prognosis
- Salvage Therapy
(methods)
- Stem Cell Transplantation
- Treatment Outcome
- Young Adult
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