Abstract |
The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.
|
Authors | Hidemi Takahashi |
Journal | Vaccine
(Vaccine)
Vol. 28 Suppl 2
Pg. B3-7
(May 26 2010)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 20510740
(Publication Type: Journal Article, Review)
|
Copyright | Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Chemical References |
- AIDS Vaccines
- Antigens, CD1
|
Topics |
- AIDS Vaccines
(immunology)
- Antigen Presentation
(immunology)
- Antigens, CD1
(immunology)
- Dendritic Cells
(immunology)
- HIV Infections
(immunology)
- Humans
- Immunity, Innate
- Major Histocompatibility Complex
- Species Specificity
|