HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Species-specific CD1-restricted innate immunity for the development of HIV vaccine.

Abstract
The human immune defense system is composed of two distinct elements: innate immunity located primarily at body surfaces restricted by species-specific CD1 molecules and acquired immunity found mainly in internal compartments associated with individually restricted MHC molecules. Historically, effective vaccines have focused on eliciting pathogen epitope-specific acquired immune responses to protect against infectious diseases; however, such traditional approaches to developing HIV vaccines have been unsuccessful. This review addresses the importance of activating host species-restricted innate immunity to enhance the virus epitope-specific acquired immunity that is needed for HIV vaccines.
AuthorsHidemi Takahashi
JournalVaccine (Vaccine) Vol. 28 Suppl 2 Pg. B3-7 (May 26 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID20510740 (Publication Type: Journal Article, Review)
CopyrightCopyright (c) 2009 Elsevier Ltd. All rights reserved.
Chemical References
  • AIDS Vaccines
  • Antigens, CD1
Topics
  • AIDS Vaccines (immunology)
  • Antigen Presentation (immunology)
  • Antigens, CD1 (immunology)
  • Dendritic Cells (immunology)
  • HIV Infections (immunology)
  • Humans
  • Immunity, Innate
  • Major Histocompatibility Complex
  • Species Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: