Influence of pupil dilation on retinal nerve fibre layer measurements with spectral domain OCT.

Abstract

PURPOSE:

To evaluate the influence of pupil dilation on retinal nerve fibre layer (RNFL) measurements with spectral domain optical coherence tomography (OCT).

PATIENTS AND METHODS:

In total, 29 healthy individuals and 26 glaucoma patients underwent RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl Zeiss Meditec Inc.) before and 30-40 min after pupil dilation with one drop of tropicamide 1%. Average thickness, quadrant thickness, and clock-hour thickness measurements were compared with the paired Student's t-test. We also compared the quality scores of the images obtained pre- and post-pupil dilation.

RESULTS:

Mean ages in the glaucoma and control groups were 58.3+/-13.4 and 41.6+/-16.4 years respectively (P<0.001). Mean deviation values were -6.96+6.31 dB in the glaucoma group and -1.26+0.79 dB in the control group (P<0.001). Mean RNFL measurements obtained in the glaucoma group were significantly lower than those obtained in the control group (P<0.001). There were no statistically significant differences between mean quality scores obtained before and after dilation neither in the glaucoma group (7.73+/-0.92 vs 7.54+/-1.10, P=0.232) nor in the control group (8.14+/-0.88 vs 8.00+/-0.71, P=0.380). There was no statistically significant difference between mean RNFL measurements obtained pre- and post-pupil dilation neither among normal individuals (P>0.05), nor among glaucoma patients (P>0.05).

CONCLUSION:

The results of this study indicate that RNFL measurements obtained with spectral domain OCT are not influenced by pupil size.

• Authors: G C Massa, V G Vidotti, F Cremasco, A P C Lupinacci, V P Costa
• Journal: Eye (London, England) (Eye (Lond)) Vol. 24 Issue 9 Pg. 1498-502 (Sep 2010) ISSN: 1476-5454 [Electronic] England
• PMID: 20508653 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Case-Control Studies
• Female
• Glaucoma (pathology)
• Humans
• Male
• Middle Aged
• Nerve Fibers (pathology)
• Optic Disk (anatomy & histology, pathology)
• Pupil (physiology)
• Tomography, Optical Coherence (methods)